4OBE
Crystal Structure of GDP-bound Human KRas
Summary for 4OBE
| Entry DOI | 10.2210/pdb4obe/pdb |
| Related | 4LDJ 4NMM |
| Descriptor | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total) |
| Functional Keywords | small gtpase, signal transduction, gdp binding, gtp binding, hydrolase |
| Biological source | Homo sapiens (human) |
| Cellular location | Cell membrane; Lipid-anchor; Cytoplasmic side: P01116 |
| Total number of polymer chains | 2 |
| Total formula weight | 39592.63 |
| Authors | Hunter, J.C.,Gurbani, D.,Chen, Z.,Westover, K.D. (deposition date: 2014-01-07, release date: 2014-06-04, Last modification date: 2023-09-20) |
| Primary citation | Hunter, J.C.,Gurbani, D.,Ficarro, S.B.,Carrasco, M.A.,Lim, S.M.,Choi, H.G.,Xie, T.,Marto, J.A.,Chen, Z.,Gray, N.S.,Westover, K.D. In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C. Proc.Natl.Acad.Sci.USA, 111:8895-8900, 2014 Cited by PubMed: 24889603DOI: 10.1073/pnas.1404639111 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.24 Å) |
Structure validation
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