4OAU

Complete human RNase L in complex with biological activators.

Summary for 4OAU

• Entry DOI: 10.2210/pdb4oau/pdb
• Related: 4OAV
• Descriptor: 2-5A-dependent ribonuclease, RNA (5'-R(P*A*AP*A)-2'), ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: rnase l, rnasel, 2-5a, 2', 5'-oligoadenylate, interferon, ken, pseudokinase, kinase, inflammation, ire1, ridd, regulated rna decay, splicing cleavage, hpc1, hereditary prostate cancer 1, rnase l kinase-homology and ken domain-containing, innate immunity, interferon response, antiviral response, 2-5a (2', 5'-linked oligoadenylate)and rna, hydrolase-rna complex, hydrolase/rna
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: Q05823
• Total number of polymer chains: 2
• Total formula weight: 80834.82

Authors

Han, Y.,Donovan, J.,Rath, S.,Whitney, G.,Chitrakar, A.,Korennykh, A. (deposition date: 2014-01-06, release date: 2014-03-12, Last modification date: 2024-02-28)

• Primary citation: Han, Y.,Donovan, J.,Rath, S.,Whitney, G.,Chitrakar, A.,Korennykh, A.; Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response.; Science, 343:1244-1248, 2014; PubMed: 24578532; DOI: 10.1126/science.1249845

Experimental method

X-RAY DIFFRACTION (2.6 Å)