4O6F

Structural Basis of Estrogen Receptor Alpha Methylation Mediated by Histone Methyltransferase SmyD2

Summary for 4O6F

Entry DOI	10.2210/pdb4o6f/pdb
Descriptor	N-lysine methyltransferase SMYD2, Estrogen receptor, ZINC ION, ... (7 entities in total)
Functional Keywords	histone methyltransferase, smyd2, estrogen receptor er alpha, methylation, estrogen signaling, transferase
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm, cytosol (By similarity): Q9NRG4 Isoform 1: Nucleus. Isoform 3: Nucleus. Nucleus: P03372
Total number of polymer chains	2
Total formula weight	52273.31
Authors	Jiang, Y.,Trescott, L.,Holcomb, J.,Brunzelle, J.,Sirinupong, N.,Shi, X.,Yang, Z. (deposition date: 2013-12-20, release date: 2014-03-26, Last modification date: 2023-09-20)
Primary citation	Jiang, Y.,Trescott, L.,Holcomb, J.,Zhang, X.,Brunzelle, J.,Sirinupong, N.,Shi, X.,Yang, Z. Structural Insights into Estrogen Receptor alpha Methylation by Histone Methyltransferase SMYD2, a Cellular Event Implicated in Estrogen Signaling Regulation. J.Mol.Biol., 426:3413-3425, 2014 Cited by PubMed: 24594358 DOI: 10.1016/j.jmb.2014.02.019 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.822 Å)

Structure validation