4O33

Crystal Structure of human PGK1 3PG and terazosin(TZN) ternary complex

Summary for 4O33

• Entry DOI: 10.2210/pdb4o33/pdb
• Related: 4O3F
• Descriptor: Phosphoglycerate kinase 1, [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl][(2R)-tetrahydrofuran-2-yl]methanone, 3-PHOSPHOGLYCERIC ACID, ... (4 entities in total)
• Functional Keywords: enzyme-drug complex, transferase-transferase activitor complex, transferase-transferase activator complex, transferase/transferase activator
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P00558
• Total number of polymer chains: 1
• Total formula weight: 45234.06

Authors

Li, X.L.,Finci, L.I.,Wang, J.H. (deposition date: 2013-12-18, release date: 2014-10-29, Last modification date: 2023-09-20)

• Primary citation: Chen, X.,Zhao, C.,Li, X.,Wang, T.,Li, Y.,Cao, C.,Ding, Y.,Dong, M.,Finci, L.,Wang, J.H.,Li, X.,Liu, L.; Terazosin activates Pgk1 and Hsp90 to promote stress resistance.; Nat.Chem.Biol., 11:19-25, 2015; PubMed: 25383758; DOI: 10.1038/nchembio.1657

Experimental method

X-RAY DIFFRACTION (2.1 Å)