4O1X

Crystal structure of human thymidylate synthase double mutant C195S-Y202C

Summary for 4O1X

• Entry DOI: 10.2210/pdb4o1x/pdb
• Related: 4O1U
• Descriptor: Thymidylate synthase, SULFATE ION, CHLORIDE ION, ... (6 entities in total)
• Functional Keywords: dimer-dimer interface modification, active conformation, methyltransferase, nucleotide biosynthesis, transferase
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : P04818 P04818
• Total number of polymer chains: 4
• Total formula weight: 150394.03

Authors

Pozzi, C.,Mangani, S. (deposition date: 2013-12-16, release date: 2015-01-21, Last modification date: 2023-03-01)

• Primary citation: Costantino, L.,Ferrari, S.,Santucci, M.,Salo-Ahen, O.M.H.,Carosati, E.,Franchini, S.,Lauriola, A.,Pozzi, C.,Trande, M.,Gozzi, G.,Saxena, P.,Cannazza, G.,Losi, L.,Cardinale, D.,Venturelli, A.,Quotadamo, A.,Linciano, P.,Tagliazucchi, L.,Moschella, M.G.,Guerrini, R.,Pacifico, S.,Luciani, R.,Genovese, F.,Henrich, S.,Alboni, S.,Santarem, N.,da Silva Cordeiro, A.,Giovannetti, E.,Peters, G.J.,Pinton, P.,Rimessi, A.,Cruciani, G.,Stroud, R.M.,Wade, R.C.,Mangani, S.,Marverti, G.,D'Arca, D.,Ponterini, G.,Costi, M.P.; Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth.; Elife, 11:-, 2022; PubMed: 36475542; DOI: 10.7554/eLife.73862

Experimental method

X-RAY DIFFRACTION (2.32 Å)