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4O1P

Crystal Structure of RNase L in complex with 2-5A and AMP-PNP

Summary for 4O1P
Entry DOI10.2210/pdb4o1p/pdb
Related4O1O
DescriptorRibonuclease L, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (5 entities in total)
Functional Keywordsankyrin repeat-kinase-rnase, rna cleavage, 2-5a, transferase, hydrolase
Biological sourceSus scrofa (pig)
Total number of polymer chains4
Total formula weight332192.94
Authors
Huang, H.,Zeqiraj, E.,Ceccarelli, D.F.,Sicheri, F. (deposition date: 2013-12-16, release date: 2014-02-05, Last modification date: 2023-09-20)
Primary citationHuang, H.,Zeqiraj, E.,Dong, B.,Jha, B.K.,Duffy, N.M.,Orlicky, S.,Thevakumaran, N.,Talukdar, M.,Pillon, M.C.,Ceccarelli, D.F.,Wan, L.C.,Juang, Y.C.,Mao, D.Y.,Gaughan, C.,Brinton, M.A.,Perelygin, A.A.,Kourinov, I.,Guarne, A.,Silverman, R.H.,Sicheri, F.
Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.
Mol.Cell, 53:221-234, 2014
Cited by
PubMed: 24462203
DOI: 10.1016/j.molcel.2013.12.025
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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