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4O0Z

Structural and Biochemical Analyses of the Catalysis and Potency Impact of Inhibitor Phosphoribosylation by Human Nicotinamide Phosphoribosyltransferase

Summary for 4O0Z
Entry DOI10.2210/pdb4o0z/pdb
Related4O0Z 4O10 4O12
DescriptorNicotinamide phosphoribosyltransferase, N-{4-[(3,5-difluorophenyl)sulfonyl]benzyl}indolizine-6-carboxamide, PHOSPHATE ION, ... (4 entities in total)
Functional Keywordstransferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus: P43490
Total number of polymer chains2
Total formula weight115117.51
Authors
Oh, A.,Wang, W. (deposition date: 2013-12-14, release date: 2014-06-18, Last modification date: 2024-02-28)
Primary citationOh, A.,Ho, Y.C.,Zak, M.,Liu, Y.,Chen, X.,Yuen, P.W.,Zheng, X.,Liu, Y.,Dragovich, P.S.,Wang, W.
Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase.
Chembiochem, 15:1121-1130, 2014
Cited by
PubMed: 24797455
DOI: 10.1002/cbic.201402023
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.049 Å)
Structure validation

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