4O02

AlphaVBeta3 integrin in complex with monoclonal antibody FAB fragment.

Summary for 4O02

Entry DOI	10.2210/pdb4o02/pdb
Descriptor	Integrin alpha-V, 2-acetamido-2-deoxy-beta-D-glucopyranose, MANGANESE (II) ION, ... (12 entities in total)
Functional Keywords	protein binding
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	236044.93
Authors	Mahalingam, B.,van Agthoven, J.,Xiong, J.,Arnaout, M.A. (deposition date: 2013-12-13, release date: 2014-04-02, Last modification date: 2020-07-29)
Primary citation	Mahalingam, B.,Van Agthoven, J.F.,Xiong, J.P.,Alonso, J.L.,Adair, B.D.,Rui, X.,Anand, S.,Mehrbod, M.,Mofrad, M.R.,Burger, C.,Goodman, S.L.,Arnaout, M.A. Atomic basis for the species-specific inhibition of alpha V integrins by monoclonal antibody 17E6 is revealed by the crystal structure of alpha V beta 3 ectodomain-17E6 Fab complex. J.Biol.Chem., 289:13801-13809, 2014 Cited by PubMed: 24692540 DOI: 10.1074/jbc.M113.546929 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.605 Å)

Structure validation