4NW6

Rsk2 N-terminal kinase in complex with 2-amino-7-substituted benzoxazole compound 27

Summary for 4NW6

Entry DOI	10.2210/pdb4nw6/pdb
Related	4NW5
Descriptor	Ribosomal protein S6 kinase alpha-3, 7-(1H-benzimidazol-7-yl)-N-(3,4,5-trimethoxyphenyl)-1,3-benzoxazol-2-amine (3 entities in total)
Functional Keywords	kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus (By similarity): P51812
Total number of polymer chains	1
Total formula weight	37621.42
Authors	Appleton, B.A. (deposition date: 2013-12-05, release date: 2014-02-19, Last modification date: 2024-02-28)
Primary citation	Costales, A.,Mathur, M.,Ramurthy, S.,Lan, J.,Subramanian, S.,Jain, R.,Atallah, G.,Setti, L.,Lindvall, M.,Appleton, B.A.,Ornelas, E.,Feucht, P.,Warne, B.,Doyle, L.,Basham, S.E.,Aronchik, I.,Jefferson, A.B.,Shafer, C.M. 2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors. Bioorg.Med.Chem.Lett., 24:1592-1596, 2014 Cited by PubMed: 24534486 DOI: 10.1016/j.bmcl.2014.01.058 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.74 Å)

Structure validation