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4NW3

Crystal structure of MLL CXXC domain in complex with a CpG DNA

Summary for 4NW3
Entry DOI10.2210/pdb4nw3/pdb
DescriptorHistone-lysine N-methyltransferase 2A, 5'-D(*GP*CP*CP*AP*TP*CP*GP*AP*TP*GP*GP*C)-3', ZINC ION (3 entities in total)
Functional Keywordshistone-lysine n-methyltransferase, cpg island, cg island, structural genomics consortium, sgc, dna binding protein-dna complex, dna binding protein/dna
Biological sourceHomo sapiens (human)
Cellular locationNucleus . MLL cleavage product N320: Nucleus. MLL cleavage product C180: Nucleus: Q03164
Total number of polymer chains3
Total formula weight16262.92
Authors
Bian, C.,Tempel, W.,Chao, X.,Walker, J.R.,Bountra, C.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Structural Genomics Consortium (SGC) (deposition date: 2013-12-05, release date: 2014-04-23, Last modification date: 2023-09-20)
Primary citationXu, C.,Liu, K.,Lei, M.,Yang, A.,Li, Y.,Hughes, T.R.,Min, J.
DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 26:85-95.e3, 2018
Cited by
PubMed: 29276034
DOI: 10.1016/j.str.2017.11.022
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.82 Å)
Structure validation

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