4NS0

The C2A domain of Rabphilin 3A in complex with PI(4,5)P2

Summary for 4NS0

Entry DOI	10.2210/pdb4ns0/pdb
Related	4LT7 4NP9
Descriptor	Rabphilin-3A, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, SULFATE ION, ... (4 entities in total)
Functional Keywords	c2 domain, calcium binding, phospholipid binding, rabphilin-3a, c2a, synaptic exocytosis metal-binding, protein transport, c-2 domain fold, exophilin-1
Biological source	Rattus norvegicus (brown rat,rat,rats)
Cellular location	Cell junction, synapse (By similarity): P47709
Total number of polymer chains	1
Total formula weight	16148.11
Authors	Guillen, J.,Ferrer-Orta, C.,Buxaderas, M.,Perez-sanchez, D.,Guerrero-Valero, M.,Luengo-Gil, G.,Pous, J.,Guerra, P.,Gomez-Fernandez, J.C.,Verdaguer, N.,Corbalan-Garcia, S. (deposition date: 2013-11-27, release date: 2013-12-25, Last modification date: 2023-11-08)
Primary citation	Guillen, J.,Ferrer-Orta, C.,Buxaderas, M.,Perez-Sanchez, D.,Guerrero-Valero, M.,Luengo-Gil, G.,Pous, J.,Guerra, P.,Gomez-Fernandez, J.C.,Verdaguer, N.,Corbalan-Garcia, S. Structural insights into the Ca2+ and PI(4,5)P2 binding modes of the C2 domains of rabphilin 3A and synaptotagmin 1. Proc.Natl.Acad.Sci.USA, 110:20503-20508, 2013 Cited by PubMed: 24302762 DOI: 10.1073/pnas.1316179110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation