4NR8

Crystal structure of the first bromodomain of human BRD4 in complex with an isoxazolyl-benzimidazole ligand

Summary for 4NR8

• Entry DOI: 10.2210/pdb4nr8/pdb
• Descriptor: Bromodomain-containing protein 4, POTASSIUM ION, 5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-2-(2-phenylethyl)-1H-benzimidazole, ... (5 entities in total)
• Functional Keywords: structural genomics consortium, sgc, chemical tool, small molecule inhibitor, transcription, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: O60885
• Total number of polymer chains: 1
• Total formula weight: 15631.09

Authors

Filippakopoulos, P.,Picaud, S.,Felletar, I.,Hay, D.,Fedorov, O.,Martin, S.,von Delft, F.,Brennan, P.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2013-11-26, release date: 2013-12-25, Last modification date: 2023-09-20)

• Primary citation: Filippakopoulos, P.,Hay, D.,von Delft, F.,Edwards, A.M.,Picaud, S.,Fedorov, O.,Brennan, P.,Bountra, C.; Crystal structure of the first bromodomain of human BRD4 in complex with an isoxazolyl-benzimidazole ligand; To be Published,

Experimental method

X-RAY DIFFRACTION (1.635 Å)