4NJ3

Modulating the interaction between CDK2 and Cyclin A with a Quinoline-based inhibitor

Summary for 4NJ3

Entry DOI	10.2210/pdb4nj3/pdb
Descriptor	Cyclin-dependent kinase 2, 6-(3-chlorophenyl)-2-{[(2S)-3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-yl]carbamoyl}quinoline-4-carboxylic acid (3 entities in total)
Functional Keywords	cell cycle, inhibition, cyclin-dependent kinase, cancer, atp-binding, cell division, mitosis, nucleotide-binding, phosphorylation, transferase, serine/threonine-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941
Total number of polymer chains	1
Total formula weight	34539.44
Authors	Fischmann, T.O.,Hruza, A.W. (deposition date: 2013-11-08, release date: 2013-11-27, Last modification date: 2014-01-08)
Primary citation	Deng, Y.,Shipps, G.W.,Zhao, L.,Siddiqui, M.A.,Popovici-Muller, J.,Curran, P.J.,Duca, J.S.,Hruza, A.W.,Fischmann, T.O.,Madison, V.S.,Zhang, R.,McNemar, C.W.,Mayhood, T.W.,Syto, R.,Annis, A.,Kirschmeier, P.,Lees, E.M.,Parry, D.A.,Windsor, W.T. Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor. Bioorg.Med.Chem.Lett., 24:199-203, 2014 Cited by PubMed: 24332088 DOI: 10.1016/j.bmcl.2013.11.041 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.848 Å)

Structure validation