4NGM

Crystal Structure of Glutamate Carboxypeptidase II in a complex with urea-based inhibitor

Summary for 4NGM

Entry DOI	10.2210/pdb4ngm/pdb
Related	4NGN 4NGP 4NGQ 4NGR 4NGS 4NGT
Descriptor	Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
Functional Keywords	hydrolase, glutamate carboxypeptidase ii, psma, naaladase, urea-based inhibitor, caboxypeptidase, glycoprotein, metallopeptidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	87191.31
Authors	Tykvart, J.,Pachl, P. (deposition date: 2013-11-02, release date: 2014-06-18, Last modification date: 2020-07-29)
Primary citation	Tykvart, J.,Schimer, J.,Barinkova, J.,Pachl, P.,Postova-Slavetinska, L.,Majer, P.,Konvalinka, J.,Sacha, P. Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery. Bioorg.Med.Chem., 22:4099-4108, 2014 Cited by PubMed: 24954515 DOI: 10.1016/j.bmc.2014.05.061 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.84 Å)

Structure validation