4NGE

Crystal Structure of Human Presequence Protease in Complex with Amyloid-beta (1-40)

Summary for 4NGE

Entry DOI	10.2210/pdb4nge/pdb
Related	4L3T
Descriptor	Presequence protease, mitochondrial, Beta-amyloid protein 40, ZINC ION, ... (8 entities in total)
Functional Keywords	m16 metalloprotease, alzheimer's disease, zinc metalloendoprotease, monomethyllysine, dimethyllysine, s-(dimethylarsenic)cysteine, mitochondrial matrix, hydrolase-protein binding complex, hydrolase/protein binding
Biological source	Homo sapiens (human) More
Cellular location	Mitochondrion matrix: Q5JRX3 Membrane; Single-pass type I membrane protein: P05067
Total number of polymer chains	6
Total formula weight	241758.94
Authors	King, J.V.,Liang, W.G.,Tang, W.J. (deposition date: 2013-11-01, release date: 2014-05-14, Last modification date: 2014-07-23)
Primary citation	King, J.V.,Liang, W.G.,Scherpelz, K.P.,Schilling, A.B.,Meredith, S.C.,Tang, W.J. Molecular basis of substrate recognition and degradation by human presequence protease. Structure, 22:996-1007, 2014 Cited by PubMed: 24931469 DOI: 10.1016/j.str.2014.05.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.704 Å)

Structure validation