4NGD

Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 12-mer siRNA having 5'-p and UU-3' ends (1.95 Angstrom resolution)

Summary for 4NGD

• Entry DOI: 10.2210/pdb4ngd/pdb
• Related: 4NGB 4NGC 4NGF 4NGG 4NH3 4NH5 4NH6 4NHA
• Descriptor: Endoribonuclease Dicer, 5'-R(P*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*UP*U)-3', SULFATE ION, ... (5 entities in total)
• Functional Keywords: paz domain, platform domain, connector helix, sirna, rnase iii domain, endoribonuclease, pre-mirna, hydrolase-rna complex, hydrolase/rna
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : Q9UPY3
• Total number of polymer chains: 2
• Total formula weight: 39121.98

Authors

Tian, Y.,Simanshu, D.K.,Patel, D.J. (deposition date: 2013-11-01, release date: 2014-03-05, Last modification date: 2023-09-20)

• Primary citation: Tian, Y.,Simanshu, D.K.,Ma, J.B.,Park, J.E.,Heo, I.,Kim, V.N.,Patel, D.J.; A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.; Mol.Cell, 53:606-616, 2014; PubMed: 24486018; DOI: 10.1016/j.molcel.2014.01.003

Experimental method

X-RAY DIFFRACTION (1.958 Å)