4NGA

Factor viia in complex with the inhibitor (2R)-2-[(1-aminoisoquinolin-6-yl)amino]-2-[3-ethoxy-4-(propan-2-yloxy)phenyl]-N-[2-(propan-2-ylsulfonyl)benzyl]ethanamide

Summary for 4NGA

• Entry DOI: 10.2210/pdb4nga/pdb
• Related: 4NG9
• Descriptor: Factor VIIa (Heavy Chain), Factor VIIa (Light Chain), (2R)-2-[(1-aminoisoquinolin-6-yl)amino]-2-[3-ethoxy-4-(propan-2-yloxy)phenyl]-N-[2-(propan-2-ylsulfonyl)benzyl]ethanamide, ... (7 entities in total)
• Functional Keywords: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 35425.43

Authors

Wei, A.,Anumula, R. (deposition date: 2013-11-01, release date: 2014-01-08, Last modification date: 2023-09-20)

• Primary citation: Zhang, X.,Jiang, W.,Jacutin-Porte, S.,Glunz, P.W.,Zou, Y.,Cheng, X.,Nirschl, A.H.,Wurtz, N.R.,Luettgen, J.M.,Rendina, A.R.,Luo, G.,Harper, T.M.,Wei, A.,Anumula, R.,Cheney, D.L.,Knabb, R.M.,Wong, P.C.,Wexler, R.R.,Priestley, E.S.; Design and Synthesis of Phenylpyrrolidine Phenylglycinamides As Highly Potent and Selective TF-FVIIa Inhibitors.; ACS Med Chem Lett, 5:188-192, 2014; PubMed: 24900796; DOI: 10.1021/ml400453z

Experimental method

X-RAY DIFFRACTION (2.15 Å)