4NDI
Human Aprataxin (Aptx) AOA1 variant K197Q bound to RNA-DNA, AMP, and Zn - product complex
Summary for 4NDI
Entry DOI | 10.2210/pdb4ndi/pdb |
Related | 3SZQ 4NDF 4NDG 4NDH |
Descriptor | Aprataxin, 5'-R(P*G)-D(P*TP*TP*AP*TP*GP*AP*TP*TP*C)-3', 5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3', ... (10 entities in total) |
Functional Keywords | protein-dna complex, dna repair, 5'-dna end processing, histidine triad domain, hit domain, zinc finger, 5'-dna end recognition, dna binding protein-rna-dna complex, dna binding protein/rna/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus, nucleoplasm. Isoform 12: Cytoplasm: Q7Z2E3 |
Total number of polymer chains | 6 |
Total formula weight | 55898.31 |
Authors | Schellenberg, M.J.,Tumbale, P.S.,Williams, R.S. (deposition date: 2013-10-26, release date: 2013-12-18, Last modification date: 2023-09-20) |
Primary citation | Tumbale, P.,Williams, J.S.,Schellenberg, M.J.,Kunkel, T.A.,Williams, R.S. Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity. Nature, 506:111-115, 2013 Cited by PubMed: 24362567DOI: 10.1038/nature12824 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report