4NDH

Human Aprataxin (Aptx) bound to DNA, AMP, and Zn - product complex

Summary for 4NDH

• Entry DOI: 10.2210/pdb4ndh/pdb
• Related: 3SZQ 4NDF 4NDG 4NDI
• Descriptor: Aprataxin, 5'-D(P*GP*TP*TP*CP*TP*AP*GP*AP*AP*C)-3', ADENOSINE MONOPHOSPHATE, ... (5 entities in total)
• Functional Keywords: protein-dna complex, dna repair, 5'-dna end processing, histidine triad domain, hit domain, zinc finger, 5'-dna end recognition, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus, nucleoplasm. Isoform 12: Cytoplasm: Q7Z2E3
• Total number of polymer chains: 6
• Total formula weight: 55520.84

Authors

Schellenberg, M.J.,Tumbale, P.S.,Williams, R.S. (deposition date: 2013-10-26, release date: 2013-12-18, Last modification date: 2023-09-20)

• Primary citation: Tumbale, P.,Williams, J.S.,Schellenberg, M.J.,Kunkel, T.A.,Williams, R.S.; Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.; Nature, 506:111-115, 2013; PubMed: 24362567; DOI: 10.1038/nature12824

Experimental method

X-RAY DIFFRACTION (1.848 Å)