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4NDG

Human Aprataxin (Aptx) bound to RNA-DNA and Zn - adenosine vanadate transition state mimic complex

Summary for 4NDG
Entry DOI10.2210/pdb4ndg/pdb
Related3SZQ 4NDF 4NDH 4NDI
DescriptorAprataxin, 5'-R(P*G)-D(P*TP*TP*AP*TP*GP*AP*TP*TP*C)-3', 5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3', ... (6 entities in total)
Functional Keywordsprotein-dna complex, dna repair, 5'-dna end processing, histidine triad domain, hit domain, zinc finger, 5'-dna end recognition, dna binding protein-rna-dna complex, dna binding protein/rna/dna
Biological sourceHomo sapiens (human)
Cellular locationNucleus, nucleoplasm. Isoform 12: Cytoplasm: Q7Z2E3
Total number of polymer chains6
Total formula weight55556.78
Authors
Schellenberg, M.J.,Tumbale, P.S.,Williams, R.S. (deposition date: 2013-10-26, release date: 2013-12-18, Last modification date: 2023-09-20)
Primary citationTumbale, P.,Williams, J.S.,Schellenberg, M.J.,Kunkel, T.A.,Williams, R.S.
Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.
Nature, 506:111-115, 2013
Cited by
PubMed: 24362567
DOI: 10.1038/nature12824
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.541 Å)
Structure validation

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