4NC5

Human sialidase 2 in complex with 2,3-difluorosialic acid (covalent intermediate)

Summary for 4NC5

Entry DOI	10.2210/pdb4nc5/pdb
Related	2A75 2AH2
Descriptor	Sialidase-2, 5-acetamido-3,5-dideoxy-3-fluoro-D-erythro-alpha-L-manno-non-2-ulopyranosonic acid, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	human neuraminidase, sialidase, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	42892.79
Authors	Buchini, S.,Gallat, F.-X.,Greig, I.R.,Kim, J.-H.,Wakatsuki, S.,Chavas, L.M.G.,Withers, S.G. (deposition date: 2013-10-24, release date: 2013-11-06, Last modification date: 2023-09-20)
Primary citation	Buchini, S.,Gallat, F.X.,Greig, I.R.,Kim, J.H.,Wakatsuki, S.,Chavas, L.M.,Withers, S.G. Tuning mechanism-based inactivators of neuraminidases: mechanistic and structural insights. Angew.Chem.Int.Ed.Engl., 53:3382-3386, 2014 Cited by PubMed: 24591206 DOI: 10.1002/anie.201309675 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.513 Å)

Structure validation