4N4W

Structure of the human smoothened receptor in complex with SANT-1.

Summary for 4N4W

• Entry DOI: 10.2210/pdb4n4w/pdb
• Related: 4JKV
• Descriptor: Cytochrome b(562),Smoothened homolog, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (E)-N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine, ... (8 entities in total)
• Functional Keywords: human smoothened receptor, antitumor agent, novel protein engineering, gpcr network, membrane protein, psi-biology, structural genomics, gpcr, membrane, transport protein
• Biological source: Shigella flexneri 5 str. 8401; More
• Total number of polymer chains: 1
• Total formula weight: 55387.42

Authors

Wang, C.,Wu, H.,Han, G.W.,Cherezov, V.,Stevens, R.C.,GPCR Network (GPCR) (deposition date: 2013-10-08, release date: 2014-01-22, Last modification date: 2023-09-20)

• Primary citation: Wang, C.,Wu, H.,Evron, T.,Vardy, E.,Han, G.W.,Huang, X.P.,Hufeisen, S.J.,Mangano, T.J.,Urban, D.J.,Katritch, V.,Cherezov, V.,Caron, M.G.,Roth, B.L.,Stevens, R.C.; Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.; Nat Commun, 5:4355-4355, 2014; PubMed: 25008467; DOI: 10.1038/ncomms5355

Experimental method

X-RAY DIFFRACTION (2.8 Å)