4MY2

Crystal Structure of Norrin in fusion with Maltose Binding Protein

Summary for 4MY2

Entry DOI	10.2210/pdb4my2/pdb
Related PRD ID	PRD_900001
Descriptor	Maltose-binding periplasmic protein, Norrin fusion protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose (3 entities in total)
Functional Keywords	cystine-knot growth factor, wnt signaling, cysteine-rich protein, angiogenesis, eye development, wnt/beta-catenin signaling, frizzled 4 receptor, lrp5/6, extracellular, fusion protein, signaling protein
Biological source	Escherichia coli O157:H7 More
Total number of polymer chains	1
Total formula weight	53177.46
Authors	Ke, J.,Jurecky, C.,Chen, C.,Gu, X.,Parker, N.,Williams, B.O.,Melcher, K.,Xu, H.E. (deposition date: 2013-09-27, release date: 2013-11-13, Last modification date: 2023-09-20)
Primary citation	Ke, J.,Harikumar, K.G.,Erice, C.,Chen, C.,Gu, X.,Wang, L.,Parker, N.,Cheng, Z.,Xu, W.,Williams, B.O.,Melcher, K.,Miller, L.J.,Xu, H.E. Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex. Genes Dev., 27:2305-2319, 2013 Cited by PubMed: 24186977 DOI: 10.1101/gad.228544.113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation