4MX1

Structure of ricin A chain bound with 2-amino-4-oxo-N-(2-(3-phenylureido)ethyl)-3,4-dihydropteridine-7-carboxamide

Summary for 4MX1

• Entry DOI: 10.2210/pdb4mx1/pdb
• Related: 1BR6 1IFT 1RTC 3PX8 4HUP 4HV3 4MX5
• Descriptor: Ricin A chain, 2-amino-4-oxo-N-{2-[(phenylcarbamoyl)amino]ethyl}-3,4-dihydropteridine-7-carboxamide, SULFATE ION, ... (5 entities in total)
• Functional Keywords: toxin, hydrolase, ribosome-inactivating protein, n-glycosidase, pterin, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Ricinus communis (Castor bean)
• Total number of polymer chains: 1
• Total formula weight: 30740.49

Authors

Robertus, J.D.,Wiget, P.A.,Manzano, L.A.,Pruet, J.M.,Gao, G.,Saito, R.,Jasheway, K.R.,Monzingo, A.F.,Anslyn, E.V. (deposition date: 2013-09-25, release date: 2014-01-15, Last modification date: 2023-09-20)

• Primary citation: Wiget, P.A.,Manzano, L.A.,Pruet, J.M.,Gao, G.,Saito, R.,Monzingo, A.F.,Jasheway, K.R.,Robertus, J.D.,Anslyn, E.V.; Sulfur incorporation generally improves Ricin inhibition in pterin-appended glycine-phenylalanine dipeptide mimics.; Bioorg.Med.Chem.Lett., 23:6799-6804, 2013; PubMed: 24432385

Experimental method

X-RAY DIFFRACTION (1.59 Å)