4MQT

Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620

Summary for 4MQT

• Entry DOI: 10.2210/pdb4mqt/pdb
• Related: 3UON 4MQS
• Descriptor: Muscarinic acetylcholine receptor M2, Nanobody 9-8, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, ... (4 entities in total)
• Functional Keywords: g protein-coupled receptor, muscarinic acetylcholine receptor, allosteric modulation, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 54015.33

Authors

Kruse, A.C.,Ring, A.M.,Manglik, A.,Hu, J.,Hu, K.,Eitel, K.,Huebner, H.,Pardon, E.,Valant, C.,Sexton, P.M.,Christopoulos, A.,Felder, C.C.,Gmeiner, P.,Steyaert, J.,Weis, W.I.,Garcia, K.C.,Wess, J.,Kobilka, B.K. (deposition date: 2013-09-16, release date: 2013-11-27, Last modification date: 2023-09-20)

• Primary citation: Kruse, A.C.,Ring, A.M.,Manglik, A.,Hu, J.,Hu, K.,Eitel, K.,Hubner, H.,Pardon, E.,Valant, C.,Sexton, P.M.,Christopoulos, A.,Felder, C.C.,Gmeiner, P.,Steyaert, J.,Weis, W.I.,Garcia, K.C.,Wess, J.,Kobilka, B.K.; Activation and allosteric modulation of a muscarinic acetylcholine receptor.; Nature, 504:101-106, 2013; PubMed: 24256733; DOI: 10.1038/nature12735

Experimental method

X-RAY DIFFRACTION (3.7 Å)