4MNE

Crystal structure of the BRAF:MEK1 complex

Summary for 4MNE

• Entry DOI: 10.2210/pdb4mne/pdb
• Related: 2Y4I 4MNF
• Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, Serine/threonine-protein kinase B-raf, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (7 entities in total)
• Functional Keywords: raf, mapk, kinase domain, atp-binding, erk, ras, pak, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: Q02750; Nucleus (By similarity): P15056
• Total number of polymer chains: 8
• Total formula weight: 297709.25

Authors

Sudhamsu, J.,Haling, J.R.,Morales, T.,Brandhuber, B.,Hymowitz, S.G. (deposition date: 2013-09-10, release date: 2014-06-18, Last modification date: 2023-09-20)

• Primary citation: Haling, J.R.,Sudhamsu, J.,Yen, I.,Sideris, S.,Sandoval, W.,Phung, W.,Bravo, B.J.,Giannetti, A.M.,Peck, A.,Masselot, A.,Morales, T.,Smith, D.,Brandhuber, B.J.,Hymowitz, S.G.,Malek, S.; Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling.; Cancer Cell, 26:402-413, 2014; PubMed: 25155755; DOI: 10.1016/j.ccr.2014.07.007

Experimental method

X-RAY DIFFRACTION (2.8483 Å)