4MKT

Human Leukotriene A4 Hydrolase in complex with Pro-Gly-Pro analogue and 4-(4-benzylphenyl)thiazol-2-amine

Summary for 4MKT

Entry DOI	10.2210/pdb4mkt/pdb
Related	4DPR 4L2L
Descriptor	Leukotriene A-4 hydrolase, ZINC ION, 1-{4-oxo-4-[(2S)-pyrrolidin-2-yl]butanoyl}-L-proline, ... (7 entities in total)
Functional Keywords	leukotriene a4 hydrolase, metalloprotein, hydrolase, protease, zinc binding
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P09960
Total number of polymer chains	1
Total formula weight	70430.23
Authors	Stsiapanava, A.,Rinaldo-Matthis, A.,Haeggstrom, J.Z. (deposition date: 2013-09-05, release date: 2014-03-12, Last modification date: 2023-09-20)
Primary citation	Stsiapanava, A.,Olsson, U.,Wan, M.,Kleinschmidt, T.,Rutishauser, D.,Zubarev, R.A.,Samuelsson, B.,Rinaldo-Matthis, A.,Haeggstrom, J.Z. Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor. Proc.Natl.Acad.Sci.USA, 111:4227-4232, 2014 Cited by PubMed: 24591641 DOI: 10.1073/pnas.1402136111 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.618 Å)

Structure validation