4MHA

Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1817

Summary for 4MHA

• Entry DOI: 10.2210/pdb4mha/pdb
• Related: 2BRB 2POC 3BPR 3TCP 4M3Q 4MH7
• Descriptor: Tyrosine-protein kinase Mer, CHLORIDE ION, 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-(4-sulfamoylbenzyl)pyrimidine-5-carboxamide, ... (5 entities in total)
• Functional Keywords: tyrosine kinase, acute lymphoblastic leukemia, rational structure-based drug design, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Membrane ; Single-pass type I membrane protein : Q12866
• Total number of polymer chains: 2
• Total formula weight: 72969.07

Authors

Zhang, W.,Mciver, A.,Stashko, M.A.,Deryckere, D.,Branchford, B.R.,Hunter, D.,Kireev, D.B.,Miley, D.B.M.,Norris-Drouin, J.,Stewart, W.M.,Lee, M.,Sather, S.,Zhou, Y.,Dipaola, J.A.,Machius, M.,Janzen, W.P.,Earp, H.S.,Graham, D.K.,Frye, S.,Wang, X. (deposition date: 2013-08-29, release date: 2014-05-21, Last modification date: 2023-09-20)

• Primary citation: Zhang, W.,McIver, A.L.,Stashko, M.A.,DeRyckere, D.,Branchford, B.R.,Hunter, D.,Kireev, D.,Miley, M.J.,Norris-Drouin, J.,Stewart, W.M.,Lee, M.,Sather, S.,Zhou, Y.,Di Paola, J.A.,Machius, M.,Janzen, W.P.,Earp, H.S.,Graham, D.K.,Frye, S.V.,Wang, X.; Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis.; J.Med.Chem., 56:9693-9700, 2013; PubMed: 24219778; DOI: 10.1021/jm4013888

Experimental method

X-RAY DIFFRACTION (2.59 Å)