4MF2

Structure of human DNA polymerase beta complexed with O6MG as the template base in a 1-nucleotide gapped DNA

Summary for 4MF2

Entry DOI	10.2210/pdb4mf2/pdb
Related	1BPX 3ISB 4MF8 4MFA 4MFC 4MFF
Descriptor	DNA polymerase beta, synthetic template DNA, synthetic upstream primer, ... (6 entities in total)
Functional Keywords	protein-dna complex, polymerase x family, dna polymerase, transferase-dna complex, transferase/dna
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: P06746
Total number of polymer chains	4
Total formula weight	46606.52
Authors	Koag, M.C.,Min, K.,Monzingo, A.F.,Lee, S. (deposition date: 2013-08-27, release date: 2014-04-16, Last modification date: 2024-02-28)
Primary citation	Koag, M.C.,Lee, S. Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase beta. J.Am.Chem.Soc., 136:5709-5721, 2014 Cited by PubMed: 24694247 DOI: 10.1021/ja500172d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation