4MDR

Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain D190A mutant, in complex with a sorting peptide from the amyloid precursor protein (APP)

Summary for 4MDR

• Entry DOI: 10.2210/pdb4mdr/pdb
• Related: 3L81
• Descriptor: AP-4 complex subunit mu-1, Amyloid beta A4 protein (3 entities in total)
• Functional Keywords: immunoglobulin-like beta-sandwich, adaptor protein complex, golgi apparatus, sorting signal recognition, alzheimer's disease, amyloid precursor protein, protein transport-protein binding complex, protein transport/protein binding
• Biological source: Homo sapiens (human); More
• Cellular location: Golgi apparatus, trans-Golgi network: O00189; Membrane; Single-pass type I membrane protein: P05067
• Total number of polymer chains: 2
• Total formula weight: 34372.03

Authors

Ross, B.H.,Lin, Y.,Corales, E.A.,Burgos, P.V.,Mardones, G.A. (deposition date: 2013-08-23, release date: 2014-03-12, Last modification date: 2023-09-20)

• Primary citation: Ross, B.H.,Lin, Y.,Corales, E.A.,Burgos, P.V.,Mardones, G.A.; Structural and Functional Characterization of Cargo-Binding Sites on the mu 4-Subunit of Adaptor Protein Complex 4.; Plos One, 9:e88147-e88147, 2014; PubMed: 24498434; DOI: 10.1371/journal.pone.0088147

Experimental method

X-RAY DIFFRACTION (1.85 Å)