4MDK

Cdc34-ubiquitin-CC0651 complex

Summary for 4MDK

• Entry DOI: 10.2210/pdb4mdk/pdb
• Descriptor: Ubiquitin-conjugating enzyme E2 R1, Ubiquitin, 4,5-dideoxy-5-(3',5'-dichlorobiphenyl-4-yl)-4-[(methoxyacetyl)amino]-L-arabinonic acid, ... (4 entities in total)
• Functional Keywords: ubiquitin conjugating enzyme domain, e2 ligase inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P49427; Ubiquitin: Cytoplasm (By similarity): P0CG48
• Total number of polymer chains: 8
• Total formula weight: 119342.64

Authors

Ceccarelli, D.F.,Orlicky, S.,Tyers, M.,Sicheri, F. (deposition date: 2013-08-22, release date: 2013-12-11, Last modification date: 2023-09-20)

• Primary citation: Huang, H.,Ceccarelli, D.F.,Orlicky, S.,St-Cyr, D.J.,Ziemba, A.,Garg, P.,Plamondon, S.,Auer, M.,Sidhu, S.,Marinier, A.,Kleiger, G.,Tyers, M.,Sicheri, F.; E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.; Nat.Chem.Biol., 10:156-163, 2014; PubMed: 24316736; DOI: 10.1038/nchembio.1412

Experimental method

X-RAY DIFFRACTION (2.6095 Å)