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4MDF

Structure of bacterial polynucleotide kinase Michaelis complex bound to GTP and DNA

Summary for 4MDF
Entry DOI10.2210/pdb4mdf/pdb
Related4GP6 4GP7 4JST 4JSY 4JT2 4JT4 4MDE
DescriptorMetallophosphoesterase, DNA (5'-D(*CP*CP*TP*GP*T)-3'), GUANOSINE-5'-TRIPHOSPHATE, ... (6 entities in total)
Functional Keywordsrna repair, p-loop phosphotransferase, transferase, hydrolase-dna complex, transferase-dna complex, transferase/dna
Biological sourceClostridium thermocellum
More
Total number of polymer chains4
Total formula weight43203.75
Authors
Shuman, S.,Das, U.,Wang, L.K.,Smith, P.,Jacewicz, A. (deposition date: 2013-08-22, release date: 2013-11-06, Last modification date: 2024-02-28)
Primary citationDas, U.,Wang, L.K.,Smith, P.,Jacewicz, A.,Shuman, S.
Structures of bacterial polynucleotide kinase in a Michaelis complex with GTP*Mg2+ and 5'-OH oligonucleotide and a product complex with GDP*Mg2+ and 5'-PO4 oligonucleotide reveal a mechanism of general acid-base catalysis and the determinants of phosphoacceptor recognition.
Nucleic Acids Res., 42:1152-1161, 2014
Cited by
PubMed: 24150947
DOI: 10.1093/nar/gkt936
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.727 Å)
Structure validation

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