4MBS

Crystal Structure of the CCR5 Chemokine Receptor

Summary for 4MBS

• Entry DOI: 10.2210/pdb4mbs/pdb
• Descriptor: Chimera protein of C-C chemokine receptor type 5 and Rubredoxin, 4,4-difluoro-N-[(1S)-3-{(3-exo)-3-[3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-1-phenylpropyl]cyclohexanecarboxamide, ZINC ION, ... (5 entities in total)
• Functional Keywords: human ccr5 chemokine receptor, anti-hiv agent, novel protein engineering, gpcr network, membrane protein, psi-biology, structural genomics, seven transmembrane helices, g protein-coupled receptor, membrane, signaling protein
• Biological source: Homo sapiens; More
• Cellular location: Cell membrane ; Multi-pass membrane protein : P51681
• Total number of polymer chains: 2
• Total formula weight: 99756.11

Authors

Tan, Q.,Zhu, Y.,Han, G.W.,Li, J.,Fenalti, G.,Liu, H.,Cherezov, V.,Stevens, R.C.,GPCR Network (GPCR),Zhao, Q.,Wu, B. (deposition date: 2013-08-19, release date: 2013-09-11, Last modification date: 2023-09-20)

• Primary citation: Tan, Q.,Zhu, Y.,Li, J.,Chen, Z.,Han, G.W.,Kufareva, I.,Li, T.,Ma, L.,Fenalti, G.,Li, J.,Zhang, W.,Xie, X.,Yang, H.,Jiang, H.,Cherezov, V.,Liu, H.,Stevens, R.C.,Zhao, Q.,Wu, B.; Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex.; Science, 341:1387-1390, 2013; PubMed: 24030490; DOI: 10.1126/science.1241475

Experimental method

X-RAY DIFFRACTION (2.71 Å)