4M5S

Human alphaB crystallin core domain in complex with C-terminal peptide

Summary for 4M5S

• Entry DOI: 10.2210/pdb4m5s/pdb
• Related: 4M5T
• Descriptor: Alpha-crystallin B chain, SUCCINIC ACID, ... (4 entities in total)
• Functional Keywords: small heat shock protein, amyloid, chaperone
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P02511 P02511
• Total number of polymer chains: 2
• Total formula weight: 11248.65

Authors

Laganowsky, A.,Cascio, D.,Sawaya, M.R.,Eisenberg, D. (deposition date: 2013-08-08, release date: 2014-04-09, Last modification date: 2024-02-28)

• Primary citation: Hochberg, G.K.,Ecroyd, H.,Liu, C.,Cox, D.,Cascio, D.,Sawaya, M.R.,Collier, M.P.,Stroud, J.,Carver, J.A.,Baldwin, A.J.,Robinson, C.V.,Eisenberg, D.S.,Benesch, J.L.,Laganowsky, A.; The structured core domain of alpha B-crystallin can prevent amyloid fibrillation and associated toxicity.; Proc.Natl.Acad.Sci.USA, 111:E1562-E1570, 2014; PubMed: 24711386; DOI: 10.1073/pnas.1322673111

Experimental method

X-RAY DIFFRACTION (1.37 Å)