4M11
Crystal Structure of Murine Cyclooxygenase-2 Complex with Meloxicam
Summary for 4M11
| Entry DOI | 10.2210/pdb4m11/pdb |
| Related | 3NT1 4FM5 4LLZ 4M10 |
| Descriptor | Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
| Functional Keywords | nsaid, cox, dioxygenase, peroxidase, glycosylation, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Mus musculus (mouse) |
| Total number of polymer chains | 4 |
| Total formula weight | 261913.25 |
| Authors | Xu, S.,Banerjee, S.,Hermanson, D.J.,Marnett, L.J. (deposition date: 2013-08-02, release date: 2014-01-22, Last modification date: 2023-09-20) |
| Primary citation | Xu, S.,Hermanson, D.J.,Banerjee, S.,Ghebreselasie, K.,Clayton, G.M.,Garavito, R.M.,Marnett, L.J. Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network. J.Biol.Chem., 289:6799-6808, 2014 Cited by PubMed: 24425867DOI: 10.1074/jbc.M113.517987 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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