4M0E

Structure of human acetylcholinesterase in complex with dihydrotanshinone I

Summary for 4M0E

Entry DOI	10.2210/pdb4m0e/pdb
Related	4M0F
Descriptor	Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Dihydrotanshinone I, ... (7 entities in total)
Functional Keywords	acetylcholinesterase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	121123.32
Authors	Cheung, J.,Gary, E.N.,Shiomi, K.,Rosenberry, T.L. (deposition date: 2013-08-01, release date: 2013-10-16, Last modification date: 2023-09-20)
Primary citation	Cheung, J.,Gary, E.N.,Shiomi, K.,Rosenberry, T.L. Structures of human acetylcholinesterase bound to dihydrotanshinone I and territrem B show peripheral site flexibility. ACS Med Chem Lett, 4:1091-1096, 2013 Cited by PubMed: 24900610 DOI: 10.1021/ml400304w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation