4LZ1

X-ray structure of the complex between human thrombin and the TBA deletion mutant lacking thymine 12 nucleobase

Summary for 4LZ1

• Entry DOI: 10.2210/pdb4lz1/pdb
• Related: 3QLP 4DIH 4DII 4LZ4
• Related PRD ID: PRD_000020
• Descriptor: Thrombin light chain, Thrombin heavy chain, Thrombin Binding Aptamer, ... (8 entities in total)
• Functional Keywords: protein-dna complex, blood coagulation, aptamer, inhibitor-dna complex, dna aptamer, g-quadruplex, serine protease, hydrolase, abasic furan, dna thymine nucleobase deletion, blood, hydrolase-dna complex, hydrolase-hydrolase inhibitor-dna complex, hydrolase/hydrolase inhibitor/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 39232.99

Authors

Pica, A.,Russo Krauss, I.,Merlino, A.,Sica, F. (deposition date: 2013-07-31, release date: 2014-01-08, Last modification date: 2020-07-29)

• Primary citation: Pica, A.,Russo Krauss, I.,Merlino, A.,Nagatoishi, S.,Sugimoto, N.,Sica, F.; Dissecting the contribution of thrombin exosite I in the recognition of thrombin binding aptamer.; Febs J., 280:6581-6588, 2013; PubMed: 24128303; DOI: 10.1111/febs.12561

Experimental method

X-RAY DIFFRACTION (1.65 Å)