4LWH

Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ5

Summary for 4LWH

• Entry DOI: 10.2210/pdb4lwh/pdb
• Related: 4LWE 4LWF 4LWG 4LWI
• Descriptor: Heat shock protein HSP 90-alpha, N-{3-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazol-5-yl}cyclopropanecarboxamide (3 entities in total)
• Functional Keywords: rossmann fold, atp binding, molecularchaperone, chaperone
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P07900
• Total number of polymer chains: 1
• Total formula weight: 23870.07

Authors

Li, J.,Shi, F.,Xiong, B.,He, J. (deposition date: 2013-07-27, release date: 2014-07-30, Last modification date: 2023-11-08)

• Primary citation: Chen, D.,Shen, A.,Li, J.,Shi, F.,Chen, W.,Ren, J.,Liu, H.,Xu, Y.,Wang, X.,Yang, X.,Sun, Y.,Yang, M.,He, J.,Wang, Y.,Zhang, L.,Huang, M.,Geng, M.,Xiong, B.,Shen, J.; Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.; Eur.J.Med.Chem., 87:765-781, 2014; PubMed: 25313505; DOI: 10.1016/j.ejmech.2014.09.065

Experimental method

X-RAY DIFFRACTION (1.7 Å)