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4LWE

Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ2

Summary for 4LWE
Entry DOI10.2210/pdb4lwe/pdb
Related4LWF 4LWG 4LWH 4LWI
DescriptorHeat shock protein HSP 90-alpha, N-[3-(5-chloro-2,4-dihydroxyphenyl)-4-(4-methoxyphenyl)-1,2-oxazol-5-yl]acetamide (3 entities in total)
Functional Keywordsrossmann fold, atp binding, molecularchaperone, chaperone
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P07900
Total number of polymer chains1
Total formula weight23638.18
Authors
Li, J.,Shi, F.,Xiong, B.,He, J. (deposition date: 2013-07-27, release date: 2014-07-30, Last modification date: 2023-11-08)
Primary citationChen, D.,Shen, A.,Li, J.,Shi, F.,Chen, W.,Ren, J.,Liu, H.,Xu, Y.,Wang, X.,Yang, X.,Sun, Y.,Yang, M.,He, J.,Wang, Y.,Zhang, L.,Huang, M.,Geng, M.,Xiong, B.,Shen, J.
Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.
Eur.J.Med.Chem., 87:765-781, 2014
Cited by
PubMed: 25313505
DOI: 10.1016/j.ejmech.2014.09.065
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.5 Å)
Structure validation

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