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4LV9

Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)

Summary for 4LV9
Entry DOI10.2210/pdb4lv9/pdb
Related4LVA 4LVB 4LVD 4LVF 4LVG 4M6P 4M6Q
DescriptorNicotinamide phosphoribosyltransferase, 7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide, PHOSPHATE ION, ... (5 entities in total)
Functional Keywordstransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus : P43490
Total number of polymer chains2
Total formula weight115311.45
Authors
Primary citationZheng, X.,Bair, K.W.,Bauer, P.,Baumeister, T.,Bowman, K.K.,Buckmelter, A.J.,Caligiuri, M.,Clodfelter, K.H.,Feng, Y.,Han, B.,Ho, Y.C.,Kley, N.,Li, H.,Liang, X.,Liederer, B.M.,Lin, J.,Ly, J.,O'Brien, T.,Oeh, J.,Oh, A.,Reynolds, D.J.,Sampath, D.,Sharma, G.,Skelton, N.,Smith, C.C.,Tremayne, J.,Wang, L.,Wang, W.,Wang, Z.,Wu, H.,Wu, J.,Xiao, Y.,Yang, G.,Yuen, P.W.,Zak, M.,Dragovich, P.S.
Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 23:5488-5497, 2013
Cited by
PubMed: 24021463
DOI: 10.1016/j.bmcl.2013.08.074
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.807 Å)
Structure validation

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