4LQM

EGFR L858R in complex with PD168393

Summary for 4LQM

• Entry DOI: 10.2210/pdb4lqm/pdb
• Related: 2J5F 4LRM
• Descriptor: Epidermal growth factor receptor, N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: egfr, kinase, pd168393, 34-jab, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• Total number of polymer chains: 1
• Total formula weight: 38116.60

Authors

Yun, C.H.,Eck, M.J. (deposition date: 2013-07-19, release date: 2014-01-15, Last modification date: 2023-09-20)

• Primary citation: Yasuda, H.,Park, E.,Yun, C.H.,Sng, N.J.,Lucena-Araujo, A.R.,Yeo, W.L.,Huberman, M.S.,Cohen, D.W.,Nakayama, S.,Ishioka, K.,Yamaguchi, N.,Hanna, M.,Oxnard, G.R.,Lathan, C.S.,Moran, T.,Sequist, L.V.,Chaft, J.E.,Riely, G.J.,Arcila, M.E.,Soo, R.A.,Meyerson, M.,Eck, M.J.,Kobayashi, S.S.,Costa, D.B.; Structural, Biochemical, and Clinical Characterization of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations in Lung Cancer.; Sci Transl Med, 5:216ra177-216ra177, 2013; PubMed: 24353160; DOI: 10.1126/scitranslmed.3007205

Experimental method

X-RAY DIFFRACTION (2.5 Å)