5K0S

Crystal structure of methionyl-tRNA synthetase MetRS from Brucella melitensis in complex with inhibitor Chem 1312

Replaces:  4LNE

Summary for 5K0S

• Entry DOI: 10.2210/pdb5k0s/pdb
• Related: 5K0T
• Descriptor: Methionine--tRNA ligase, 2-({3-[(3,5-dichlorobenzyl)amino]propyl}amino)quinolin-4(1H)-one (3 entities in total)
• Functional Keywords: ssgcid, metrs, methionyl-trna synthetase, protein biosynthesis, structural genomics, seattle structural genomics center for infectious disease, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Brucella suis biovar 1 (strain 1330)
• Cellular location: Cytoplasm : P59078
• Total number of polymer chains: 3
• Total formula weight: 182142.14

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2016-05-17, release date: 2016-05-25, Last modification date: 2023-09-27)

• Primary citation: Ojo, K.K.,Ranade, R.M.,Zhang, Z.,Dranow, D.M.,Myers, J.B.,Choi, R.,Nakazawa Hewitt, S.,Edwards, T.E.,Davies, D.R.,Lorimer, D.,Boyle, S.M.,Barrett, L.K.,Buckner, F.S.,Fan, E.,Van Voorhis, W.C.; Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.; Plos One, 11:e0160350-e0160350, 2016; PubMed: 27500735; DOI: 10.1371/journal.pone.0160350

Experimental method

X-RAY DIFFRACTION (2.45 Å)