4LIQ

Structure of the extracellular domain of human CSF-1 receptor in complex with the Fab fragment of RG7155

Summary for 4LIQ

• Entry DOI: 10.2210/pdb4liq/pdb
• Descriptor: Macrophage colony-stimulating factor 1 receptor, Fab fragment RG7155 heavy chain, Fab fragment RG7155 light chain, ... (8 entities in total)
• Functional Keywords: csf-1 receptor, receptor tyrosine kinase, antibody, fab fragment, igg like domain, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 109817.56

Authors

Benz, J.,Gorr, I.H.,Hertenberger, H.,Ries, C.H. (deposition date: 2013-07-03, release date: 2014-06-18, Last modification date: 2023-11-08)

• Primary citation: Ries, C.H.,Cannarile, M.A.,Hoves, S.,Benz, J.,Wartha, K.,Runza, V.,Rey-Giraud, F.,Pradel, L.P.,Feuerhake, F.,Klaman, I.,Jones, T.,Jucknischke, U.,Scheiblich, S.,Kaluza, K.,Gorr, I.H.,Walz, A.,Abiraj, K.,Cassier, P.A.,Sica, A.,Gomez-Roca, C.,de Visser, K.E.,Italiano, A.,Le Tourneau, C.,Delord, J.P.,Levitsky, H.,Blay, J.Y.,Ruttinger, D.; Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy; Cancer Cell, 25:846-859, 2014; PubMed: 24898549; DOI: 10.1016/j.ccr.2014.05.016

Experimental method

X-RAY DIFFRACTION (2.6 Å)