4LGU

Crystal structure of clAP1 BIR3 bound to T3226692

Summary for 4LGU

• Entry DOI: 10.2210/pdb4lgu/pdb
• Related: 4LGE
• Related PRD ID: PRD_001141
• Descriptor: Baculoviral IAP repeat-containing protein 2, ZINC ION, (3S,8aR)-N-((R)-chroman-4-yl)-2-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)octahydropyrrolo[1,2-a]pyrazine-3-carboxamide, ... (4 entities in total)
• Functional Keywords: lap family, 3 bir repeats, card domain, 1 ring-type zinc finger, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q13490
• Total number of polymer chains: 2
• Total formula weight: 27771.84

Authors

Dougan, D.R.,Mol, C.D.,Snell, G.P. (deposition date: 2013-06-28, release date: 2013-08-28, Last modification date: 2022-12-21)

• Primary citation: Asano, M.,Hashimoto, K.,Saito, B.,Shiokawa, Z.,Sumi, H.,Yabuki, M.,Yoshimatsu, M.,Aoyama, K.,Hamada, T.,Morishita, N.,Dougan, D.R.,Mol, C.D.,Yoshida, S.,Ishikawa, T.; Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists.; Bioorg.Med.Chem., 21:5725-5737, 2013; PubMed: 23928071; DOI: 10.1016/j.bmc.2013.07.020

Experimental method

X-RAY DIFFRACTION (2 Å)