4LAC

Crystal Structure of Protein Phosphatase 2A (PP2A) and PP2A phosphatase activator (PTPA) complex with ATPgammaS

Summary for 4LAC

Entry DOI	10.2210/pdb4lac/pdb
Descriptor	Serine/threonine-protein phosphatase 2A activator, PP2A Scaffold Subunit A, Truncated, an internal deletion of PP2A A, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ... (8 entities in total)
Functional Keywords	pp2a, ptpa, protein phosphatase, signaling pathway regulation, chaperone, hydrolase-signaling protein complex, hydrolase/signaling protein
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: Q15257 P67775
Total number of polymer chains	3
Total formula weight	100398.89
Authors	Guo, F.,Stanevich, V.,Wlodarchak, N.,Satyshur, K.A.,Xing, Y. (deposition date: 2013-06-19, release date: 2013-10-09, Last modification date: 2023-09-20)
Primary citation	Guo, F.,Stanevich, V.,Wlodarchak, N.,Sengupta, R.,Jiang, L.,Satyshur, K.A.,Xing, Y. Structural basis of PP2A activation by PTPA, an ATP-dependent activation chaperone. Cell Res., 24:190-203, 2014 Cited by PubMed: 24100351 DOI: 10.1038/cr.2013.138 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.82 Å)

Structure validation