Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4L7S

Kinase domain mutant of human Itk in complex with an aminobenzothiazole inhibitor

Summary for 4L7S
Entry DOI10.2210/pdb4l7s/pdb
Related4KIO
DescriptorTyrosine-protein kinase ITK/TSK, trans-4-({4-[difluoro(4-fluorophenyl)methyl]-6-[(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)amino]pyrimidin-2-yl}amino)cyclohexanol, SULFATE ION, ... (4 entities in total)
Functional Keywordskinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: Q08881
Total number of polymer chains2
Total formula weight61558.13
Authors
Somers, D.O. (deposition date: 2013-06-14, release date: 2014-01-22, Last modification date: 2024-02-28)
Primary citationAlder, C.M.,Ambler, M.,Campbell, A.J.,Champigny, A.C.,Deakin, A.M.,Harling, J.D.,Harris, C.A.,Longstaff, T.,Lynn, S.,Maxwell, A.C.,Mooney, C.J.,Scullion, C.,Singh, O.M.,Smith, I.E.,Somers, D.O.,Tame, C.J.,Wayne, G.,Wilson, C.,Woolven, J.M.
Identification of a Novel and Selective Series of Itk Inhibitors via a Template-Hopping Strategy.
ACS Med Chem Lett, 4:948-952, 2013
Cited by
PubMed: 24900590
DOI: 10.1021/ml400206q
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.03 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon