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4L33

Tankyrase 2 in complex with cyanomethyl 4-(4-oxo-4H-chromen-2-yl)benzoate

Summary for 4L33
Entry DOI10.2210/pdb4l33/pdb
Related4BS4 4HKI 4KZL 4KZQ 4KZU 4L09 4L0B 4L0I 4L0S 4L0T 4L0V 4L10 4L2F 4L2G 4L2K 4L31 4L32 4L34
DescriptorTankyrase-2, ZINC ION, SULFATE ION, ... (8 entities in total)
Functional Keywordsprotein-ligand complex, diphtheria toxin like fold, transferase, adp-ribosylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
More
Cellular locationCytoplasm: Q9H2K2 Q9H2K2
Total number of polymer chains4
Total formula weight56065.49
Authors
Narwal, M.,Haikarainen, T.,Lehtio, L. (deposition date: 2013-06-05, release date: 2013-10-30, Last modification date: 2023-09-20)
Primary citationNarwal, M.,Koivunen, J.,Haikarainen, T.,Obaji, E.,Legala, O.E.,Venkannagari, H.,Joensuu, P.,Pihlajaniemi, T.,Lehtio, L.
Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
J.Med.Chem., 56:7880-7889, 2013
Cited by
PubMed: 24116873
DOI: 10.1021/jm401463y
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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