4L1B

Crystal Structure of p110alpha complexed with niSH2 of p85alpha

Summary for 4L1B

• Entry DOI: 10.2210/pdb4l1b/pdb
• Related: 4L23 4L2Y
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, SULFATE ION, ... (4 entities in total)
• Functional Keywords: atp binding, signaling protein-transferase-inhibitor complex, signaling protein/transferase/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 163592.53

Authors

Zhang, J.,Zhao, Y.L.,Chen, Y.Y.,Huang, M.,Jiang, F. (deposition date: 2013-06-03, release date: 2014-01-01, Last modification date: 2023-09-20)

• Primary citation: Zhao, Y.,Zhang, X.,Chen, Y.,Lu, S.,Peng, Y.,Wang, X.,Guo, C.,Zhou, A.,Zhang, J.,Luo, Y.,Shen, Q.,Ding, J.,Meng, L.,Zhang, J.; Crystal Structures of PI3K alpha Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design.; ACS Med Chem Lett, 5:138-142, 2014; PubMed: 24900786; DOI: 10.1021/ml400378e

Experimental method

X-RAY DIFFRACTION (2.586 Å)