4KY2

Transthyretin in complex with the fluorescent folding sensor (E)-7-hydroxy-3-(4-hydroxy-3,5-dimethylstyryl)-4-methyl-2H-chromen-2-one

Summary for 4KY2

Entry DOI	10.2210/pdb4ky2/pdb
Related	1DVS 3CN0 3CN1 3CN3 3CN4
Descriptor	Transthyretin, 7-hydroxy-3-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]-4-methyl-2H-chromen-2-one (3 entities in total)
Functional Keywords	tetramer, hormone, transport protein, t4, retinol binding protein
Biological source	Homo sapiens (human)
Cellular location	Secreted: P02766
Total number of polymer chains	2
Total formula weight	28199.43
Authors	Connelly, S.,Wilson, I.A.,Choi, S. (deposition date: 2013-05-28, release date: 2013-08-28, Last modification date: 2023-09-20)
Primary citation	Myung, N.,Connelly, S.,Kim, B.,Park, S.J.,Wilson, I.A.,Kelly, J.W.,Choi, S. Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors. Chem.Commun.(Camb.), 49:9188-9190, 2013 Cited by PubMed: 23989101 DOI: 10.1039/c3cc44667k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.13 Å)

Structure validation