4KV5

scFv GC1009 in complex with TGF-beta1.

Summary for 4KV5

Entry DOI	10.2210/pdb4kv5/pdb
Related	3EO0 3EO1 4KXZ
Descriptor	Transforming growth factor beta-1 proprotein, Single-chain variable fragment GC1009 (2 entities in total)
Functional Keywords	cysteine knot, fab, tgf-beta receptor mimetic, tgf-beta, tgf-beta receptor, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	8
Total formula weight	157865.60
Authors	Wei, R.,Moulin, A.G.,Mathieu, M. (deposition date: 2013-05-22, release date: 2014-09-24, Last modification date: 2019-12-25)
Primary citation	Moulin, A.,Mathieu, M.,Lawrence, C.,Bigelow, R.,Levine, M.,Hamel, C.,Marquette, J.P.,Le Parc, J.,Loux, C.,Ferrari, P.,Capdevila, C.,Dumas, J.,Dumas, B.,Rak, A.,Bird, J.,Qiu, H.,Pan, C.Q.,Edmunds, T.,Wei, R.R. Structures of a pan-specific antagonist antibody complexed to different isoforms of TGF beta reveal structural plasticity of antibody-antigen interactions. Protein Sci., 23:1698-1707, 2014 Cited by PubMed: 25209176 DOI: 10.1002/pro.2548 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation